Abdominal Ultrasound

Abdominal ultrasound is specifically used to detect any abnormalities of the abdominal organs and other structures in the upper abdominal regions. An abdominal ultrasound can aid in determining the cause of abdominal pain or monitoring an abdominal aneurysm. It is mainly used to detect gall stones and tumors. Problems of the liver such as jaundice, cirrhosis or fatty deposits can be evaluated with abdominal ultrasound. Enlarged spleen, Pancreatitis and blocked bile ducts can be diagnosed with an abdominal ultrasound. Extreme obesity and gas or other materials in the stomach or intestines can affect the accuracy of an abdominal ultrasound. An abdominal ultrasound can aid placement of needle or other instrument during biopsy. Any fluid buildup in the abdominal cavity can be detected.

Abnormal liver enzyme

Abnormal liver enzyme detection and estimation provides a comprehensive foundation for the identification of inflammatory diseases associated with the liver. These values are raised when liver cells are damaged. Routine liver function test helps in the estimation and detection of abnormal liver enzymes.

In many cases liver enzyme abnormalities are caused because of hepatocellular injury. This condition results when the liver cells are damaged producing leaky membranes. The intracellular enzymes enter the blood stream as a result of these leaky membranes. The predominant intracellular liver enzymes which are analyzed indicating the hepatocellular damage are aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Hepatitis is one of major causes for the hepatocellular damage.

Cholestasis is another condition, resulting in the production of abnormal liver enzymes. It is caused because of biliary obstruction or hepatic infiltration. The resulting enzymes produced because of these conditions include alkaline phosphatase (ALT) and gamma glutamyl transpeptidase (GGT).

Risk factors due to abnormal liver enzymes

The risk factors pertaining to the onset of liver disease are based upon factors such as behavior, medications and systemic illness. The patients categorized based on the behavior include IV drug users, history of multiple sex partners, alcohol abuse and tattoos. The patients categorized based on the medication include acetaminophen and anticonvulsant drug users. Systemic conditions such as diabetes, auto immune diseases, obesity and metastatic cancers are major risk factor indicatives of hepatocellular damage which elevate the abnormal liver enzyme values.

Liver function test

Alanine aminotransferase (ALT): It is also known as serum glutamic pyruvic transaminase (SGPT) analysis. It helps in the detection of hepatocellular damage due underlying conditions such as hepatitis. The reference range for the ALT test is 9 -72 u/l.

Alkaline phosphatase (ALP): This test used in the detection of biliary obstruction in liver and also bone disorders. The results are correlated with other liver function tests to diagnose liver cell damage. The reference range is 38-126 u/l

Aspartate aminotransferase (AST): AST is also used in the detection of liver cell damage and membrane leakage of the liver cells. The reference range is 8- 50 u/l.

Bilirubin: Bilirubin diagnostic test is administered to detect conditions such as cirrhosis, hepatitis and presence of gall stones. It is predominantly ordered in the case of newborns to detect the incidence of jaundice. The reference range for total bilirubin is 0.2-1.3 mg/dl.

Albumin: Albumin test signifies the presence of liver disorder or nephrotic syndrome. Low albumin levels indicate the presence of liver damage. The reference range is 3.9- 5.0 g/dl.

Lactate dehydrogenase (LDH): LDH values indicate the presence of tissue damage. It is used to detect tissue damage associated liver, kidney and cardiac origins. The reference range for LDH is 313-618 u/l.

Comprehensive metabolic panel (CMP): Comprehensive metabolic panel pertaining to liver disease is very significant in the detection of underlying liver disorders such as hepatitis especially in newborns. It also helps in the identification of liver damage caused because of alcohol consumption.

Gamma glutamyl transferase (GGT): This test acts as a precursor for the estimation of alkaline phosphatase values pertaining to hepatocellular damage and biliary obstruction. GGT and ALP tests are interrelated in case of hepatic and bone disorders.

Total protein: Total protein levels are measured by evaluating the albumin and globulin ratios. The reference range for total protein is 6.3- 8.2 g/dl. The decrease in total protein value indicates the onset of liver or kidney disease.

Interventional Radiology

A sub-specialty of radiology, Interventional radiology - IR has contributed significantly to medical developments in recent years. Patients are diagnosed and treated using minimally invasive imaging techniques such as X-ray, MRI and ultrasound for guidance. In addition to diagnosis, new treatment options are offered by techniques in Interventional radiology (also known as Surgical Radiology)- patients are treated with lesser risk and shorter hospital stays.

The advantage of IR procedures is that they can be used in almost every organ system - be it abdomen, central nervous system, chest, heart and vascular, musculoskeletal, genito-urinary and other organs and soft tissues.

Interventional Radiologists

Patient evaluation and management are provided by Interventional radiologists, who are doctors trained in radiology and in minimally invasive procedures, skilled in interpreting X rays, ultrasounds and CT and other imaging techniques. While surgery was the only available option for a number of conditions a few years back, these days the expertise of Interventional radiologists with imaging technique enables them to guide small catheters, that are only a few millimeters in diameter and guide wires through blood vessels or other organ pathways to treat many conditions. Diseases and conditions are diagnosed and treated percutaneously with minimally invasive procedures.

Benefits and uses of Interventional radiology

This is an imaging technique using cutting-edge equipment for accurate diagnosis and treatment, a minimally invasive procedure through a small nick in the skin, minimizing the patient's discomfort and recovery time. These days, there is hardly any area in hospital medicine where IR has not impacted patient management.

These procedures require only local anesthesia, and short stays at the hospital. Sick patients who are unfit to undergo surgery can also undergo these techniques. Recovery post IR procedure is less painful than when the patient undergoes surgical procedures.

These image guided medical procedures use CT, MRI, fluoroscopy and ultrasound to view targeted areas. This makes the vessels clearly visible under imaging. A thin catheter is used to deliver the contrast material into a particular blood vessel and shows the inside of the vessel allowing the radiologist to locate blockages. Some examples of interventional radiology procedures include:

• Angiography or Angioplasty
  
• Stent placement
  
• Control bleeding with Embolization
  
• Tumor embolization
  
• Vertebroplasty and Kyphoplasty
  
• Needle biopsies for different organs including lungs and thyroid gland
  
• Tumor ablation
  
• Breast biopsy by stereotactic or ultrasound techniques
  
• Uterine artery embolization
  
• Feeding tube placement
  
• Venous access catheter placement

Using Interventional radiology

By minimizing the physical trauma to the patient, non-surgical interventions also reduce infection rates and recovery time and shorten hospital stays.

• Blood vessel disease such as narrowing of arteries leading to restricted flow of blood
  
• Expanded arteries at risk of rupture and bleeding
  
• Bleeding or hemorrhage which is the most common vascular emergency treated by IR.
  
• Blood clots in the lung
  
• Dilated veins or varicose veins that most commonly occur in the legs but can occur in the pelvis and scrotum and can be treated by blocking the vein by heat treatment or using embolization techniques.
  
• Tumor therapies in liver intended to shrink or destroy them in their primary site.
  
• Kidney and other tumors by destructive therapies
  
• Uterine fibroids which cause heavy menstrual bleeding and pain caused by benign tumors called fibroids
  
• Kidney stones that can cause pain
  
• Infection and blockage in the kidney and gall stones, one of the most common upper abdominal disorders.