Septicemia

Septicemia is a life-threatening infection; where there is bacteria in the blood. This is a form of blood poisoning and the fatality rate is nearly 50%. It is also called a systemic inflammatory response syndrome or SIRS where the whole body is inflamed due to suspected infection. Severe sepsis leads to organ failure. Infections in the lungs, urinary tract or abdomen can lead to sepsis. Other conditions that can lead to septicemia are endocarditis, meningitis and osteomyelitis. Symptoms of sepsis begin with chills, high fever and rapid breathing. The condition worsens rapidly with hypothermia and low blood pressure setting in. There is very low urine output. Blood test for platelet count, CBC, blood gases and PTT are done. CSF culture is also done to diagnose sepsis. Treatment of septicemia involves hospitalization. IV fluids and medications are administered. Plasma is often given when clotting factors are affected. Dialysis and mechanical ventilation might be required to support the kidney and lung function.

Renal Failure

Acute renal failure happens when the kidneys suddenly lose their ability to remove toxins from the urine. Typically the cause for a sudden kidney failure are acute tubular necrosis (ATN) and autoimmune kidney diseases. Other causes leading to kidney damage are acute pyelonephritis and septicemia. The symptoms indicating acute renal failure are changes in urination, lowered sensation in extremities and metallic taste in the mouth. Typical symptoms include nausea, blood in stools, swelling of feet and ankles, swelling of ankle or leg, fluid retention and fatigue. A person might also notice high blood pressure, nausea and reduced appetite. Change in mental alertness might be noticed.

A nephrologist will need to examine the patient and suggest further course of action. BUN test and blood tests for creatinine and potassium are done. Kidney ultrasound or MRI might be done to look for any stones, tumors or blockage. A person suffering acute kidney failure is hospitalized and the amount of liquid ingested in monitored. The diet has to be tailored to reduce proteins and salt. Diuretics might be prescribed for reducing fluid retention. In some cases, dialysis is done; especially when the potassium levels are abnormally high. The balance of body electrolytes is maintained.

Acute kidney failure is more common with older adults and those suffering kidney or liver disease, heart failure or diabetes. An abdominal surgery might also make you more susceptible to kidney failure. Severe dehydration, blood pressure medications and overuse of NSAIDs are other possible causes for renal failure. This condition can be life threatening if not treated in time. It can lead to chronic kidney failure or damage to the nervous system and the heart. The patient can develop very high blood pressure or loss of blood in the intestines leading to last-stage kidney disease. Treatment for kidney disease include antibiotics and iodine-based medications.

Osteomyelitis

Osteomyelitis is a medical condition that results from bone infection. The bacteria Staphylococcus aureus is usually the cause of Osteomyelitis. Other possible causes for Osteomyelitis are streptococcus and E. coli. Infection is caused either through the bloodstream or direct bone infection through open wounds or fractures. Surgery, fungal infection, injury or boils can be the source for contamination and infection. Typically the infection results in the formation of pus and abscess in the bone. The blood supply to the bone is affected and Osteomyelitis sets in. Osteomyelitis can affect adults and children. While the long bones of the limbs are usually affected in children, the pelvic or back bone of adults is affected. Chronic Osteomyelitis sets in when there is prolonged loss of blood supply to the affected bone tissue. This can happen in diabetics, dialysis patients and those who abuse drugs intravenously. Persons whose spleen has been removed may be at higher risk for Osteomyelitis.

Osteomyelitis can attack more than one bone at a time. Symptoms of Osteomyelitis are localized swelling and redness in the affected bone area. The patient feels ill and nauseous. There might be fever and pain too. In some cases, Osteomyelitis also results in swelling of feet and ankles or lower back pain. The nagging joint pain fails to respond to pain medications and there is intense pain on touching. There is weight loss and severe fatigue. Tests to diagnose this condition include bone scans and MRI of infected bones. Blood tests and cultures can help identify the type of bacterial infection so that the right course of treatment can be adopted. Blood tests will reveal higher ESR and elevated WBC count in those affected by Osteomyelitis. X-rays can reveal the extent of infection in the affected bone. A biopsy of affected bone tissue can also help identify the bacterial infection.

With early diagnosis, this infection can be treated with antibiotics. Often the antibiotics are given intravenously. Treatment for Osteomyelitis involved hospitalization and bed rest. But newer forms of oral antibiotic therapy have been successful in penetrating bone tissue. This has drastically reduced the need for prolonged hospitalization. In chronic cases of Osteomyelitis, surgical removal of dead bone tissue is required. Bone grafting is done to promote growth of new bone tissue. In rare cases, Osteomyelitis can lead to blood poisoning (septicemia) and destruction of the bone.