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Insulin resistance

Insulin resistance or Metabolic syndrome is a condition where the body's insulin is not properly utilized. This condition also called Syndrome X is often called impaired fasting glucose (IFG) or Pre-diabetes. In an attempt to compensate the insulin resistance, the body produces extra insulin that leads directly or indirectly to the metabolic abnormalities.

Causes for Syndrome X

Obesity metabolic syndrome: A large waistline or abdominal obesity, which generally is 40 inches or more for men and 35 inches or more for women.

Physical inactivity: Metabolic syndrome is associated with sedentary lifestyles like adipose tissue, reduced HDL cholesterol, increased triglycerides (fat found in blood), blood pressure and glucose in the genetically susceptible.

Aging: The prevalence of metabolic syndrome increases with age.

Diabetes Mellitus: Metabolic syndrome is found in large majority of patients with Type-2 diabetes or impaired glucose tolerance (IGT).

Coronary Heart Disease: Patients with coronary heart disease are at higher risk of developing metabolic syndrome.

Tackling Metabolic Resistance

Physical activity for at least 30 to 60 minutes a day is generally recommended. Losing weight is imperative to dealing with metabolic syndrome. Follow a healthy diet. Insulin resistance is increased by smoking cigarettes. part from weight loss and exercise, few drugs are also prescribed to reduce the LDL cholesterol levels. Drugs prescribed for this kind of treatment include statin, a fibrate drug or a combination of a statin with either niacin or a fibrate.


Hyperlipidemia is an excess of fatty substances called lipids, which largely consists of cholesterol and triglycerides in the blood. Also known as hyperlipoproteinernia, due to the fatty substances that travel in the blood, this is perhaps the only way fatty substances can remain dissolved while in circulation. Secondary causes of hypercholesterolemia include hypothyroidism, pregnancy, and kidney failure. Hyperlipidemia, along with diabetes is a major risk factor for coronary heart disease. Medications most commonly used to treat high LDL cholesterol levels are statins or simyastatin. These work by reducing the production of cholesterol within the body.

Diabetes Mellitus Type 2

Diabetes Mellitus Type 2 or non-insulin dependent diabetes is more commonly noticed. This is caused due to insufficient production of insulin by the pancreas or when the body is unable to regulate the amount of glucose in the blood. Complications of type 2 diabetes include coronary heart disease, renal failure, diabetic neuropathy and failing eyesight. Diabetes Type 2 is also referred to as late-onset diabetes.

Diabetes Mellitus Type 2 develops when the patient's body becomes insulin-resistant. Symptoms of Type 2 diabetes include blurred vision, weight loss and excessive thirst and fatigue. Yeast infection and fungal infections are common. Weight reduction can go a long way in maintaining blood sugar levels. Smoking and excessive alcohol consumption increase the risk of developing type 2 diabetes. Sedentary lifestyle and obesity also increase a person's chances of diabetes type 2. Often this type of diabetes is hereditary. Persons with excessive abdominal fat are more prone to developing diabetes type 2. Hypertension and high blood cholesterol increases a person's risk of diabetes mellitus type 2.

Blood tests for glucose tolerance help in detecting diabetes mellitus type 2. In some cases, patients suffering from diabetes mellitus type 2 are able to control their condition with diet and exercise. Follow a diet that is low in saturated fat, salt and sugar. Instead opt for high fiber vegetables and fruits. Antidiabetic medications (sulphonylureas) are prescribed for diabetic patients to increase the production of insulin and improve its efficiency. These include glibenclamide and glipizide. Insulin injections are resorted to when all these measures fail to reduce blood sugar levels.

Tags: #Insulin resistance #Hyperlipidemia #Diabetes Mellitus Type 2
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Collection of Pages - Last revised Date: April 17, 2024