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Chronic Inflammation

Inflammation is a generalized response of the body when affected by a trauma or an infection. Inflammatory response is a significant indication of the body's immune system reaction. A cascade of events usually follow inflammation based on which the form of inflammation is determined as acute or chronic. Acute inflammatory response is short lived but chronic inflammation is a progressive form.

Inflammatory response cascade consists of tissue necrosis, fibrous granulation, lymphocyte aggregation and collagen damage. Although the body's natural response with respect to tissue damage is activated; a dormant stage can also occur in some cases of chronic inflammation such as the stalemate stage in which the balance between damaged tissue and fresh tissue is not neutralized. In some cases chronic inflammatory diseases can also be caused as result of autoimmune diseases.

Clinical manifestations

Chronic inflammatory disease can occur in various parts of the body. It activates the production of macrophages and T- Cell immune response to prevent apoptosis of the healthy tissue. In most cases the diseases associated with chronic inflammatory responses are asymptomatic in the acute phase. The chronic form infectious diseases primarily occurs because of immune comprised status of the host.

Inflammatory response is also caused by irritants such as uric acid crystals, which are endogenous materials and other irritants such as silica, asbestos and prosthetic materials. Other clinical manifestations of chronic inflammatory disease are associated with underlying medical conditions such as organ specific like Hashimoto's Thyroiditis and non organ specific such as rheumatoid arthritis, Crohn's disease and inflammatory bowel disease.

Anti-inflammatory drugs are recommended in most cases for chronic inflammation. One of the most successful ways to treat persistent inflammation is to include foods that have high anti-inflammatory properties. Fruits and vegetables such as broccoli, pineapple, avocados and diary products such as yoghurt have potent anti-inflammatory properties.


Quercetin is not a nutrient but a flavonol, a sub-class of Flavonoids. Anti-inflammatory, anti-oxidant, anti-carcinogenic and cardio-protective properties of Quercetin help in fighting diseases and improve over all well-being. It helps to get rid of damaging free radical molecules. It inhibits the formation of LDL cholesterol and various enzymes that cause inflammation in the body.

Role of Quercetin

The anti-histamine properties of Quercetin play a vital role in fighting allergies, specifically seasonal allergies (pollen, mold or dust). Quercetin inhibits histamine, (the chemical released by the immune system to trigger an allergic reaction) release from immune cells and helps reduce itching red eyes, runny nose and scratchy throat. Quercetin is beneficial to people with interstitial cystitis, high blood pressure, prostatitis. Quercetin also inhibits tumor growth.

Research indicates positive use of Quercetin in treating cellular damage in brain cells. Lesser damage to cellular proteins and DNA cells have been confirmed. By improving the strength of capillaries, Quercetin helps alleviate bruises, edema, varicose veins and fragile capillaries. A study on healthy but un-trained exercisers suggested that the antioxidant and anti-inflammatory properties of Quercetin help boost endurance capacity as well as maximal oxygen capacity. Headache and stomach ache are common side effects. High dosage can however lead to complications. The most common of the Quercetin side effect is heartburn that occurs soon after taking a large dose. Acid reflux may also occur.


A phytochemical, quercetin is a plant pigment and is produced by the Flavonoids in a plant. It is found in many plants like apples, berries, onions, kale, tomatoes, broccoli and red wine, green tea, buckwheat tea and black tea. Quercetin is water soluble and it lends certain fruits, flowers and vegetables their color.

Quercetin has antioxidant and anti-inflammatory properties useful for the body. These antioxidants fight against the free radicals that cause damage to the cell. It works as an anti-inflammatory substance by stabilizing the cells that release histamine in the body. Thus it is mainly used to reduce inflammation of the prostate. It is also used to increase endurance and perk up athletic performance. Quercetin can be obtained from citrus fruits and apples and vegetables like onions, parsley and sage. Olive oil, grapes, dark cherries and dark berries are filled with the goodness of quercetin.

What quercetin does ?

Quercetin is a natural anti-histamine, anti-inflammatory and antioxidant. It boosts the immune system and increases mitochondria in the muscle and brain. Quercetin is used for treating certain conditions:

Quercetin is generally considered safe if used for a short term, when consumed orally. It is also safe when appropriate amount is given intravenously. Pregnant and lactating mothers must their doctors before using quercetin, though it is generally not recommended. Quercetin may cause headache and tingling sensation in the arms and legs. Very high doses might cause kidney damage. People using blood thinning drugs, chemotherapy, liver drugs and drugs for certain other medical conditions should not use quercetin.

Tags: #Chronic Inflammation #Quercetin #Quercetin
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Collection of Pages - Last revised Date: January 27, 2023