Hepatocarcinoma

Malignant hepatoma, which is primary cancer of the liver is termed hepatocarcinoma. Hepatocarcinoma is secondary in about 20% to either a viral hepatitide infection (hepatitis B and C) and about 80% to cirrhosis. In some cases, it is metastasis of cancer, spread from elsewhere in the body. It is also associated with chronic alcohol abuse. Hepatocellular carcinoma is relatively rare in the United States but quite common in the African and Southeast Asian countries. Infact, this is the fifth most common tumor worldwide. In some African countries the disease onsets between late teens and 30s although the normal occurrence is in patients over age 50. Hepatocarcinoma is more common in males than females.

Hepatocarcinoma patients are put under surveillance with ultrasound. Possibly the best method of diagnosis involves a CT scan of the abdomen. This is done using intravenous contrast agent and three phase scanning, enabling the radiologist to detect subtle tumors as well. Another possible alternative to a CT imaging is MRI, using contrast agents which is used to detect the presence of a tumor capsule. Diagnosis is further confirmed by percutaneous biopsy and histopathological parameters.

Treatment for hepatocarcinoma depends especially on the size of the tumor and staging. Some of the treatment options are liver transplantation, which is to replace the liver with a cadaver liver or a live donor lobe; surgical resection wherein the tumor is removed if diagnosed early; Percutaneous ethanol injections in case of solitary tumors and transcatheter arterial chemoembolization for large tumors.

Sometimes sealed source radiotherapy is used to destroy the tumor from within. Here, the radioactive particles are deposited to the area of interest using a catheter. Radiofrequency ablation uses high frequency radio waves to ablate the tumor. As an adjuvant therapy in resected patients, intra-arterial-iodine-131-lipiodol administration is performed. High intensity frequency ultrasound is a relatively new but powerful technique used to treat the tumor. Hormonal therapy and adjuvant chemotherapy are other treatment modalities adopted. Cryosurgery is yet another new technique that can destroy tumors in a variety of sites, in the brain, breast, kidney, prostrate and liver.

Leukemia

Leukemia is cancer of the white blood cells found in the blood. This serious disease is often fatal. Leukemia is caused due to either of the 2 abnormal white blood cells:

• Myeloid white blood cells are made in the bone marrow from where they travel through the bloodstream destroying foreign organisms.
  
• Lymphoid white blood cells are located in the lymph nodes and lymphatic system.
  
  

  Chronic leukemia is a situation where the disease progresses slowly. Acute leukemia is indicated by a sudden onset and is more likely to affect children and young people.

A person suffering from leukemia noticed repeated infections and unexplained bruising. There is a tendency to feel fatigued and anemic. Other symptoms include loss of weight and fever. Aching joints and bones are yet another symptom of leukemia. Symptoms of acute lymphoblastic leukemia appear very rapidly. A detailed blood test is taken for diagnosing leukemia. When it shows an abnormal number of abnormal white blood cells, it is indicative of leukemia. A bone marrow biopsy is taken to help classify the leukemia.

Treatment for leukemia includes radiotherapy, chemotherapy, immune therapy and bone marrow transplantation. Chemotherapy treatment uses cytotoxic drugs to kill abnormal cells thereby stopping their further division. But the fallout of this procedure is that often normal body cells such as those in the hair and skin are also killed. Bone marrow transplant is carried out only on children and younger patients. Marrow cells from a donor, who is generally a sibling, is replaced in the patient.

Lung Cancer

Lung cancer has been commonly associated with cigarette smoking and use of tobacco. Lung cancer can surface in any part of the lung, though most instances of lung cancer are noticed in the epithelial lining. Smoking is the cause for nearly 90%of the cases of lung cancer. Tobacco smoke contains carcinogens that contribute towards the development of lung cancer. Women smokers are at greater risk of lung cancer than men smokers. Even passive smoking is fraught with risks. Another cause for lung cancer is exposure to asbestos fibers. This gives rise to mesothelioma. A small percentage of lung cancer cases are attributed to radon gas exposure. Persons suffering from COPD (chronic obstructive pulmonary disease) at at increased risk for lung cancer. Air pollution arising from vehicular and industrial effluents can increase the risk of lung cancer.

Symptoms of lung cancer include coughing and wheezing and chest pain. A patient suffering from lung cancer may notice blood while coughing. There might be extreme fatigue and unexplained weight loss. Lung cancer patients are more likely to face repeated respiratory infections such as bronchitis and pneumonia. Other symptoms of lung cancer include difficulty in swallowing and enlargement of lymph nodes on the neck.

The physician will look into the lungs with a bronchoscope. Tissue samples are often taken for biopsy. Sputum cytology is also conducted to detect presence of lung cancer cells. Chest x-ray and examination is done. Tisue biopsy of lymph nodes is done to diagnose lung cancer. Chemotherapy and radiotherapy are used in the treatment of lung cancer.

Bibliography / Reference

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