Tamoxifen Citrate
Indication:
This hormonal agent is used for the treatment of breast cancer.
Side effects:
Transient fall in the white blood cell or platelet counts, nausea, vomiting, loss of appetite, vaginal discharge, vaginal bleeding, weight gain, increased blood calcium, rash, temporary bone pain and hot flashes.
Interactions :
1. Using with antacids may decrease tamoxifen effect. Separate dosing by at least three hours.
2. Monitor FBC closely.
3. Using with oestrogens can decrease tamoxifen effect.
4. Using with famotidine, ranitidine, or cimetidine, can decrease tamoxifen effect.
5. Using with Warfarin can increase anticoagulant effect.
Dose:
Adults: oral, 10 or 20 mg once a day.
Bibliography / Reference
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