MAO inhibitor - Antidepressant drug
MAO (Monoamine oxidase) inhibitors are a genre of drugs that are used to treat depression and Parkinson's Disease. Brand names of some MAO inhibitor drugs are Marplan, Nardil, Parnate and Eldepryl. MAO inhibitors are used in the treatment of mental depression as well as anxiety and panic attacks.
MAO inhibitors are seen to work adversely in the presence of tyramine. It leads to a build-up of tyramine thereby causing High Blood pressure and increasing the chances of a stroke. Persons on MAO inhibitors must ensure that they avoid foods that contain high levels of tyramine. Legumes, cheese, fish, ginseng, meat, shrimp paste and alcohol are foodstuffs that are high in tyramine. Other foods that must not be consumed in excess when on MAO inhibitors are chocolate, soy sauce, yogurt and sour cream.
Side Effects of MAO inhibitor: Typical side effects of MAO inhibitors are headache, fainting, muscle twitches and confusion. MAO inhibitors are known to cause increased sun sensitivity, blurred vision and drowsiness. Stomach upsets, loss of appetite and irritability can also result. Some persons on MAO inhibitors tend to experience heart palpitations, memory impairment and anxiety. It is essential to consult your physician in case you notice skin rash, fever and yellowing of the eyes or skin.
Dosage of MAO inhibitor: It is essential to check the dosage of the MAO inhibitor with your physician. Larger or more frequent doses must be avoided nor should the drug be taken for longer than prescribed. Since the effects of the MAO inhibitors take some time to be felt, it is essential to continue the dosage as directed. Dosage must be slowly tapered down. Ensure that you follow the diet restrictions that are recommended for those on MAO inhibitors.
venlafaxine
INDICATION
A new class of antidepressant medications, unrelated to the tricyclic antidepressants, used in the treatment of depression.
SIDE EFFECTS
Anxiety, somnolence, dizziness, dry mouth, nausea, abnormal ejaculation (male), impotence, headache, tremor, blurred vision, asthenia, sweating, nervousness, hypertension, and insomnia have been the most commonly reported. Changes in weight, appetite and allergic reactions have also been reported more infrequently. Other less common effects include infection, chills, chest pain, tachycardia, rash, constipation, abnormal dreams, paraesthesias, depression, urinary retention, twitching, change in taste, and
tinnitus.
INTERACTIONS and PRECAUTIONS
1. Use with caution and at a reduced dosage in those with, liver impairment.
2. Consider overall risk-benefit in those with hypertension.
3. Do not use with alcohol.
4. Do not use with Mao inhibitors--fatal interaction can result.
5. Potential for interaction with over-the-counter cold remedies, consult you physician before use.
6. Use with cimetidine could potentiate the effects of venlafaxine. A dosage reduction (venlafaxine) may be necessary in some individuals.
USUAL DOSE
Adults: oral, 75 mg per day in two to three dicided doses, taken with food. Sumatriptan
Sumatriptan, part of the family of drugs called as triptans is prescribed for the treatment of Migraine and cluster headaches. Migraine headaches are thought to be the result of dilation of blood vessels in the head. Sumatriptan causes constriction of the blood vessels thus relieving Migraine. Triptans are technically abortive migraine medications. However, Sumatriptan does not prevent or reduce the number of migraine attacks. There is another 'triptan' drug which has slightly less side effects than Sumatriptan - Rizatriptan.
Dosage and Administration: Starting dosage may be 25 mg or at the discretion of the physician. However, the Physician might want the patient to take the first dosage at his office to monitor any adverse heart events. Normal dosage is 25 mg to 100 mg or as prescribed by the Physician. Maximum dose in any 24 hours should not exceed 300 mg orally. Do not use Sumatriptan concomitantly with Ergotamine containing preparations.
Safety and efficacy has not been proved for patients over 65 years or for children.
Contraindications: The use of Sumatriptan is contraindicated in hypersensitivity, ischemic heart disease or previous myocardial infraction, Prinzmetal's angina, coronary vasospasm and controlled hyper tension. Sumatriptan should not be used unless there is a clear diagnosis of Migraine. Before use, exclude underlying cardiac disease especially in patients with risk factors. Chest symptoms may occur which mimic angina but are rarely found to be the result of vasospasm. Vasospasm may result in arrhythmia, ischemia or myocardial infarction. This drug is to be avoided for patients with impaired renal or hepatic functions.
Sumatriptan should not be administered along with ergot type migraine medications, or with MAO inhibitors. Sumatriptan and Ergotamine together can cause prolonged spasm of the blood vessels. It is essential that the use of these two medications should be separated by at least 24 hours.
Side Effects of Sumatriptan: Pain, tingling sensation, heaviness or pressure in the chest region which may be transient. Rarely severe flushing, dizziness, paresthesia, weakness, fatigue, drowsiness may occur. Transient rise in blood pressure may occur.
Bibliography / Reference
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